A factor that accelerates aging in middle-aged men has been identified

Researchers from Shanghai Jiao Tong University have concluded that two representatives of the group of so-called "forever chemicals" - perfluorononanoic acid (PFNA) and perfluorooctane sulfonamide (PFOSA) - are capable of provoking accelerated biological aging in middle-aged men. The results of the scientific work were published in the journal Frontiers in Aging.

PFAS (per- and polyfluoroalkyl substances) earned the nickname "forever chemicals" for good reason. These synthetic compounds are widely used in the production of non-stick coatings, water-repellent textiles, packaging materials, and firefighting foams. Possessing ultra-strong chemical bonds, they are virtually indestructible in the environment, accumulating in water resources, soil, and the human body. Previously, exposure to a number of these substances had already been linked to an increased risk of developing cancer, obesity, infertility, and hormonal disruptions.

As part of the study, specialists examined data from 326 individuals who participated in the U.S. National Health and Nutrition Examination Survey during the period from 1999 to 2000. In the blood samples of volunteers, scientists measured the concentration of 11 types of PFAS and also assessed DNA methylation - epigenetic changes that affect gene activity. Using 12 "epigenetic clock" models, the experts calculated the biological age of participants and compared it with their chronological age.

PFNA and PFOSA were detected in the blood of 95% of those examined. Notably, higher levels of these substances demonstrated a statistically significant correlation with accelerated epigenetic aging specifically in men aged 50 to 64. Among women, no such association was identified.

The authors of the study suggest that middle age in men may be a particularly vulnerable period when the body reacts more acutely to external stress factors. In addition, lifestyle and accompanying circumstances - such as smoking, which potentially amplifies the impact of chemical pollutants - may influence aging indicators.