A common beverage may reduce inflammation in the body, scientists have found

Compounds found in coffee may influence the cellular receptor NR4A1, which is responsible for regulating inflammatory processes and the body's stress response. This conclusion was reached by researchers from Texas A&M University. The results of their work have been published in the scientific journal Nutrients.

As reported by BAKU.WS with reference to the study, earlier epidemiological observations had already shown that regular coffee consumption is associated with reduced mortality and a lower risk of age-related diseases. However, the precise molecular mechanisms behind these beneficial effects remained poorly understood. The new study sheds light on how individual components of the beverage may affect cellular processes.

As part of the research, scientists examined the interaction of coffee and its main biologically active compounds with the NR4A1 receptor. This protein is involved in regulating the activity of genes that control cellular stress and inflammatory responses.

The study analyzed several substances characteristic of coffee beans: caffeic, ferulic, chlorogenic, and para-coumaric acids, as well as kahweol and cafestol. Experiments showed that these compounds are capable of binding to the NR4A1 receptor and altering the activity of cellular processes under its control.

At the same time, the scientists noted that different components of coffee affect the receptor in different ways. The main polyphenols demonstrate a pronounced interaction with NR4A1, whereas caffeine and quinic acid exhibit weaker and less stable activity.