Scientists have discovered that Parkinson's disease may begin not in the brain, but in the kidneys

New research overturns understanding of Parkinson's disease origin - one of the most common neurodegenerative diseases. Scientists have determined that the first pathological processes may begin not in the brain, as previously thought, but in the kidneys.

Until now, certain areas of the brain, particularly the substantia nigra where dopamine neurons are destroyed, were considered the main focus of disease development. It is the dopamine deficiency that leads to characteristic symptoms: tremor, muscle rigidity, impaired movement coordination. However, fresh data suggest that the trigger for the disease may occur much earlier and in a completely different organ.

Researchers noticed abnormalities in kidney function in patients with early-stage Parkinson's. Molecular signals and protein deposits similar to those found in the brains of patients were discovered. Additionally, some patients showed inflammatory markers and signs of oxidative stress in kidney tissue several years before neurological symptoms appeared.

Scientists suggest that the pathological protein alpha-synuclein, a key player in Parkinson's disease, may accumulate in the kidneys and trigger a chain reaction that reaches the brain through the nervous system. This discovery gives hope for earlier diagnosis and prevention of the disease.

If the hypothesis is confirmed in further studies, the approach to treating Parkinson's could change dramatically. Instead of fighting the consequences of brain destruction, doctors could target the original source of the disease - even before motor symptoms appear.

This discovery also emphasizes the importance of a systemic approach to health: organs in the human body are closely connected, and a disease manifesting in one may actually begin in another.