The cause of chronic fatigue after workouts revealed

Scientists from Brazil have discovered that the "culprit" behind fatigue, pain, and decreased immunity during excessive physical exertion is an excess of the PARP1 protein. The research results are published in the journal Molecular Metabolism (MolMeta).
It is known that excessive physical exertion without sufficient recovery can not only reduce athletic performance but also cause serious harm to the body. In extreme cases, overtraining syndrome develops: endurance deteriorates, appetite decreases, chronic fatigue accumulates, muscles ache, the risk of injuries increases, and immune and metabolic processes are disrupted.
To determine what exactly triggers such changes, scientists conducted an experiment on mice. The animals were forced to move until they reached exhaustion. After such training sessions, the rodents predictably experienced a sharp drop in performance, apathy, and stress behavior - for example, freezing or compulsive fur licking.
Analysis showed that the activity of PARP1 - a protein responsible for repairing damaged DNA - sharply increased in their muscles. Scientists explained that its function is to protect cells during stress, however, in excess, it disrupts mitochondrial function, provokes inflammation, and worsens energy metabolism.
According to one of the study's authors, Barbara Krisol, a similar clinical picture is observed in muscular dystrophy, obesity, and even in cachexia - extreme emaciation in cancer patients.
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