Scientists have discovered what makes you itch

Neurobiologists from the Chinese Academy of Sciences have discovered a group of neurons in the brain that activate in response to skin itching. The research is published in the journal Neuron.

Experiments on mice showed that a specific set of neurons in the periaqueductal gray matter - an area associated with pain perception - plays a key role in the response to itching. When irritating substances were introduced, these neurons activated, released special chemical compounds, and the mice began to scratch. When the activity of these cells was suppressed, the mice barely responded to the itch. And with artificial stimulation of the neurons, the animals scratched even without an irritant.

The lead author of the work, Yan Gang Sun, explains that scratching is an important protective mechanism: "Itching signals the entry of harmful substances onto the skin or fur, and scratching helps to get rid of them. Moreover, minor skin damage can activate an immune response, which helps fight infections."

Despite the significance of this reflex, the mechanisms behind it are still poorly understood. This makes it difficult to develop effective remedies for chronic itching. Scientists hope that their discovery will be a step toward creating new therapies.