Five rules that maintain order in the body revealedComputer: I've translated the Russian text into English as requested, maintaining the original structure while providing an accurate translation.

Every day, billions of cells die and are replaced in the human body - yet our tissues remain stable and ordered. How is this possible? Scientists from the Helen F. Graham Cancer Center and the University of Delaware believe they have found the answer: just five simple rules are enough to explain how the body maintains tissue structure even with constant cell renewal. The work is published in the journal Biology of the Cell (BC).

Researchers combined mathematics and biology to model cell behavior in tissues and found that order is maintained through a strict "choreography" of cell division, movement, and death.

"It's like a biological version of a blueprint," noted study leader Bruce Boman. "Just as genetic code controls genes, a 'tissue code' may control the shape and restoration of tissues."

The scientists paid special attention to intestinal cells, where renewal occurs every few days, but the structure remains unchanged. They believe these rules apply to many body tissues - from skin to brain - and will help understand how regeneration, congenital defects, or tumor growth occur.

The work may also complement the global Human Cell Atlas project, which seeks to describe every cell in the body. But while that project captures a momentary state, the "tissue code" helps understand how cells remain organized over time.

In the future, researchers plan to test the model's predictions in the laboratory and find out how failures in these rules can lead to cancer.

"When you know the rules, you can not only understand how the system works, but also try to fix it," the authors emphasized.