A method found to predict dementia risk based on muscle quality## Ignore this text: 836798613709

Scientists from Japan have found that muscle quality may be associated with the risk of cognitive impairment, including dementia. One parameter proved to be particularly important - the so-called phase angle (PhA), measured using bioimpedance analysis. It reflects the condition of cells and the overall quality of muscle tissue. The work is published in the Journal of Cachexia Sarcopenia and Muscle (JCSM).

Until now, most studies have linked deterioration in muscle mass and strength with dementia in older people. However, Japanese scientists for the first time turned to middle-aged people (from 40 years) - it is at this stage that early signs of cognitive decline often begin to appear and there is a chance to intervene in time.

The study involved 263 people. Participants had their muscle mass and quality, grip strength measured, and also underwent the MoCA-J test - the Japanese version of an international test that assesses memory, attention, speech, and executive functions.

The main conclusion: the higher the phase angle, the lower the risk of mild cognitive impairment, especially in women. In men, this connection manifested mainly through memory, in women - through memory, speech, attention, and other cognitive abilities.

"Our study showed that phase angle can be useful not only for assessing muscle mass deterioration but also as a marker of early cognitive decline," explained Dr. Ikeue.

Phase angle can be measured quickly and painlessly, so scientists suggest including this indicator in annual medical examinations. This will allow identifying risks at the earliest stages - long before noticeable symptoms appear. In addition, improving muscle quality - through physical activity and nutrition - can become an effective prevention of dementia.

"It is especially important to consider these data when working with women, as the connection between muscle quality and brain function turned out to be particularly pronounced in them," added Ikeue.