Scientists have discovered why some elderly people are more vulnerable to diseases than others

Scientists from the Karolinska Institute have identified genes that make elderly people more vulnerable to stress and diseases. The work is published in the journal Nature Aging.
Frailty is a condition in which the body loses resilience and becomes more susceptible to falls, illnesses, and other external factors. It increases the risk of hospitalization and mortality, but why some people face it earlier than others has remained unclear until now.
After analyzing the DNA of nearly a million people from the UK and Finland, scientists found hundreds of genetic variants associated with the development of frailty. As it turned out, genes responsible for brain function, immune system, and metabolism play an important role.
"Frailty doesn't arise from a single cause. It's a complex process associated with multiple genes, and some of them we've discovered for the first time," noted the lead author of the study, Professor Sara Hägg.
According to the scientists, knowledge of genetic markers will help identify people with an increased risk of losing body resilience in advance - possibly even in middle age, when there is a chance to slow down or prevent this process.
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