Method found to prevent brain tumor recurrence

Scientists from the National Taiwan University have created a unique post-operative gel dressing that enhances the effectiveness of radiation therapy and helps fight glioma - one of the most aggressive types of brain tumors. The results of the work are published in the Chemical Engineering Journal (CEJ).

The new gel is designed to be introduced directly into the tumor removal area immediately after surgery. Its main task is to provide prolonged and localized release of anti-tumor substances, while minimizing overall impact on the body. This form of delivery allows for targeted action on remaining cancer cells, reducing the risk of disease recurrence.

The gel implements a two-stage drug delivery system. First, carboplatin - a chemotherapeutic agent that begins to destroy glioma cells immediately after surgery - is quickly released into the wound. Then a slower release of platinum-doped calcium carbonate particles (CaCO₃:Pt) begins. These particles penetrate into the cells and continue the therapeutic effect at the intracellular level, maintaining the effect until radiation therapy begins.

Tests on orthotopic tumor models showed that this approach causes pronounced apoptosis of glioma cells and significant damage to their DNA. In combination with subsequent radiation therapy, the gel significantly reduces the risk of tumor regrowth.

The scientists remind us: high-grade gliomas develop aggressively and often recur. Standard chemoradiation therapy only slightly increases survival. Researchers hope that the new method can be used during the critical period of vulnerability after the main treatment, when residual tumor cells respond poorly to systemic chemotherapy.