A substance that intensifies skin itching has been found in vegetable oil

Researchers from the University of North Carolina have discovered that the compound EKODE, formed during the breakdown of linoleic acid found in vegetable oils, may intensify skin itching.

As reported by BAKU.WS with reference to the journal Communications Biology, experiments on mice showed that EKODE activates the Gpr35 receptor in sensory nerve cells. When scientists blocked this receptor or deleted the corresponding gene, the animals scratched significantly less frequently.

Additionally, blocking Gpr35 reduced itching in mice with skin conditions resembling psoriasis and atopic dermatitis. At the same time, the response to histamine remained unchanged, indicating the existence of a separate mechanism for the onset of itching.

The researchers suggest that the activated receptor triggers the transmission of itch signals to the spinal cord through the molecule Nppb.

EKODE had previously been detected in elevated concentrations in skin affected by psoriasis. However, the findings are currently based predominantly on animal experiments. Scientists still need to determine whether this compound acts in a similar manner on human nerve cells.